Depression and anxiety disorders in patients with multiple sclerosis: association with neurodegeneration and neurofilaments

There is increasing evidence that neurofilament light chain (NF-L) can be considered as a biomarker for neuro-axonal damage. This polypeptide released into the cerebrospinal fluid (CSF) and blood, where it quantified. The concentration of NF-L elevated in patients with multiple sclerosis (MS) psychiatric disorders. We aimed to investigate levels CSF from treated MS relationship depression or anxiety. study involved three groups: control group (individuals without inflammation), relapse-remitting (RRMS)-untreated group, RRMS-Fingo (RRMS who were fingolimod). disability was assessed by Expanded Disability Status Scale, anxiety evaluated neuropsychologist, using Hospital Anxiety Depression Beck Inventory-II, Inventory. Individual samples collected measure levels. results statistical analysis on subjects, RRMS-untreated patients, significant. between not statistically In conclusion, events such appear contribute onset clinical relapses, subclinical cases, neurodegeneration.